Oncogenicity of an Endogenous C-Type Virus Chemically Activated from Mouse Cells in Culture

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Oncogenicity of an endogenous C-type virus chemically activated from mouse cells in culture.

RNA C-type viruses are known to exist in an unexpressed form in all mouse cells. These endogenous viruses can be activated from cells in tissue culture under certain experimental conditions. The biologic activity in vivo of one class of chemically-activated C-type virus has been studied. This virus is shown to induce a specific tumor, lymphatic leukemia, in mice of a low leukemic incidence strain.

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Effect of Caffeine on Induction of Endogenous Type C Virus in Mouse Cells in Wfro1

The effect of caffeine on the expression of murine endoge nous virus in mouse cells induced by radiation and chemicals was studied. Postirradiation treatment of K-BALB cells with caffeine enhanced cell killing as well as the induction of xenotropic virus after ultraviolet light irradiation. The degree of enhancement for the virus induction was comparable to that for cell killing. On the other h...

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Effect of caffeine on induction of endogenous type C virus in mouse cells in vitro.

The effect of caffeine on the expression of murine endogenous virus in mouse cells induced by radiation and chemicals was studied. Postirradiation treatment of K-BALB cells with caffeine enhanced cell killing as well as the induction of xenotropic virus after ultraviolet light irradiation. The degree of enhancement for the virus induction was comparable to that for cell killing. On the other ha...

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ژورنال

عنوان ژورنال: Journal of Virology

سال: 1974

ISSN: 0022-538X,1098-5514

DOI: 10.1128/jvi.13.1.237-240.1974